肿瘤标志物对肺癌分期和骨转移诊断的价值

目的探讨肿瘤标志物癌胚抗原（CEA）、细胞角蛋白19的片段（CYFRA21—1）、神经稀醇酶（NSE）、糖类抗原（CA153）血清水平对肺癌分期及肺癌骨转移的辅助诊断价值。方法检测206例肺癌患者血清4种标志物水平，比较各期肺癌之间、骨转移组和无骨转移组之间的肿瘤标志物表达水平和阳性率的差异。结果骨转移组4项标志物水平均高于无骨转移组（P均〈0．05）；肺癌分期越晚，4项标志物阳性率越高；4项联检时灵敏度、准确率等均优于单项检查。结论肿瘤标志物水平的检测对肺癌骨转移的诊断、肺癌分期（特别是肺癌后期）诊断有辅助价值，联合检查优于单项检查：

The diagnosis value of serum tumor marker for bone metastasis and stages of lung cancer

Objective To approach the auxiliary diagnosis value of serum tumor markers CEA, CYFRA21-1 ,NSE and CA153 levels for bone metastasis and stages of lung cancer. Methods To collect the serum tumor markers levels of 206 lung cancer patients with whole bone scanning, to analysis the difference of the express level and positive ratio of every stage patients and between bone metastasis group and non-bone metastasis group. Results The four kinds markers levels of bone metastasis group were all higher than non-bone metastasis group（ P all 〈 0.05 ）. Four tumor markers positive ratio were increasing with lung cancer stage developing. The sensitivity and accuracy when unite four tumor markers were superior to single marker inspect. Conclusions To detect four kinds tumor markers serum levels for bone metastasis and stages of lung cancer（ special later stage of lung cancer） have assist diagnosis value.