Interactions of Endotoxin with Cortisol and Acute Phase Proteins in Septic Shock Neonates |
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| Authors: | H TOGARI S SUGIYAMA T OGINO S SUZUKI T ITO T ICHIKI K KAMIYA I WATANABE Y OGAWA Y WADA T TAKAOKA |
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| Institution: | From the Department of Pediatrics, and the first Department of Surgery, Nagoya City University, Medical School, Nagoya, Japan |
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| Abstract: | ABSTRACT. CRP, α1-acid glycoprotein and haptoglobin were studied in 13 septic shock neonates. Endotoxin was recovered from eight infants. Serum Cortisol concentration from infants with en-dotoxemia (917 ± 596 ng/ml) was significantly higher than that from infants without en-dotoxemia (398 ± 239 ng/ml). Serum Cortisol correlated well with immature neutrophil counts denned as the unit "band/neutrophil". Increased Cortisol level and immature neutrophil counts preceded the elevation of CRP, α1-acid glycoprotein and haptoglobin in four extremely premature neonates. We conclude that positive interactions between endotoxin, Cortisol and acute phase protein synthesis are present in the initial period of infection, and delayed acute phase protein synthesis is suspected in extremely premature neonates. |
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| Keywords: | Endotoxin acute phase protein sepsis neonate |
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