| 脑红蛋白与缺血缺氧性脑损伤 |
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| 引用本文： | 尹静,杨燚,李俐涛,张祥建.脑红蛋白与缺血缺氧性脑损伤[J].国际脑血管病杂志,2008,16(5). |
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| 作者姓名： | 尹静 杨燚 李俐涛 张祥建 |
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| 作者单位： | 河北医科大学第二医院神经内科,石家庄,050000 |
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| 摘 要： | 脑红蛋白(neuroglobin,Ngb)是携氧球蛋白家族成员之一,主要以单体形式存在于神经细胞中,与脑内氧供应密切相关.脑缺血缺氧能诱导Ngb高表达,并作为一种内源性神经保护因子保护神经元免受缺血缺氧性损害.文章对Ngb的分布、结构、功能及其在缺血缺氧性脑损伤中的保护作用和机制做了综述.
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| 关 键 词： | 脑红蛋白 缺血缺氧 神经保护 |
Neuroglobin and Cerebral Hypoxia/Ischemia Cerebral Injury |
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| Jing Yin,Yi Yang,Li-Tao Li,Xiang-Jian Zhang.Neuroglobin and Cerebral Hypoxia/Ischemia Cerebral Injury[J].International Journal of Cerebrovascular Diseases,2008,16(5). |
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| Authors: | Jing Yin Yi Yang Li-Tao Li Xiang-Jian Zhang |
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| Abstract: | Neuroglobin(Ngb)is one of the members of oxygen-carrying globin family.It mainly exists in neurons in a monomeric form,which is closely correlated the oxygen supply to brain.Brain hypoxia/ischemia can induce the high expression of Ngb,and as an endogenous neuroprotective factor,it protects ischemic neurons from ischemia/hypoxia injury.This article reviews the distribution,structure and function of Ngb,and its potential protective effects and mechanisms in cerebral ischemia/hypoxia cerebral injury. |
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| Keywords: | neuroglogin hypoxia/ischemia brain injury neruroprotection |
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