380例高度近视眼多焦视网膜电图特点

目的分析高度近视眼患者的多焦视网膜电图分布特征,探讨高度近视眼患者早期视网膜功能改变。方法连续收集高度近视眼患者380例（720眼）和正常对照者280例（560眼）,采用德国Roland公司生产的RETIscan多焦视觉电生理检查系统,记录一阶反应的P1波波形与数值,分析比较其5个环形视网膜区域的变化情况。结果 380例高度近视组5个环形视网膜区域的P1波平均反应密度值、振幅总和值均低于正常对照组,潜伏期值比对照组明显延长,其中以1环和2环改变最为明显,P〈0.05。结论高度近视眼患者多焦视网膜电图的反应密度、振幅均降低,潜伏期延长,以黄斑中心凹区域改变最为明显,说明高度近视眼患者的早期视网膜损害主要发生于黄斑中心凹区域。

The multifocal electroretinogram characteristics of 380 cases of high myopia

Objective To analyze the multifocal electroretinogram（mERG） characteristics of high myopia and to explore the early retinal changes of high myopic patients.Methods 380 cases（720eyes） of patients with high myopia and 280 cases（560eyes） of healthy controls were collected.The RETIscan multifocal visual-point physical inspection system produced by German Roland Company was used to record the first-order reflected wave and analyz its 5 rings retinal regions changes.Results The average response densities and the amplitude of P1 wave of 5 rings retinal regions among the 380 cases of patients with high myopia were lower than the healthy control.The latency time was significantly longer than the healthy controls.The ring 1 and ring 2 were changed significantly.Conclusions The multifocal ERG response density and the amplitudes of the patients with high myopia are lower and the latency time is delayed than the healthy persons,the most significant areas are in the macular area.It indicats that the early retinal damages occurred mainly in the macula area in high myopia.