Antigens of Mycobacterium tuberculosis recognized by antibodies during incipient, subclinical tuberculosis |
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Authors: | Singh Krishna K Dong Yuxin Belisle John T Harder Jeffrey Arora Vijay K Laal Suman |
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Institution: | Department of Pathology, New York University School of Medicine, New York, New York, USA. |
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Abstract: | Serum samples obtained from human immunodeficiency virus (HIV)-infected tuberculosis (TB) patients months prior to clinical TB were used to delineate the profile of Mycobacterium tuberculosis culture filtrate proteins recognized during subclinical TB. A subset of approximately 12 antigens was recognized by antibodies in these serum samples. Antibodies to two of these antigens (81 88]-kDa malate synthase GlcB] and MPT51) were present in serum samples obtained during incipient subclinical TB in 19 (approximately 90%) of the 21 HIV-infected TB patients tested. These antigens will be useful for devising diagnostic tests that can identify HIV-positive individuals who are at a high risk for developing clinical TB. |
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