Fischer 344 rats display age-related memory deficits in trace fear conditioning |
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Authors: | Villarreal Julissa S Dykes James R Barea-Rodriguez Edwin J |
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Affiliation: | Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA. jsvillareal@utsa.edu |
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Abstract: | A functional hippocampus is required for trace fear conditioning, which involves learning the association of a tone and shock that are separated over time. Young and aged rats received 10 trace conditioning trials. Twenty-four hours later, rats were tested for fear to the tone in a novel chamber by measuring freezing. The results showed significantly lower levels of freezing in aged rats as compared with young rats, which provides evidence of age-related memory impairments. Pseudorandom conditioning groups showed low levels of freezing, indicative of no associative memory. Age-related memory deficits were not found with delay conditioning, which suggests no age-related sensory-motor deficits. These data suggest that aging hinders the ability of the hippocampus to process information separated over time. |
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