活血化瘀方治疗慢性阻塞性肺疾病急性加重期的临床观察

目的 观察活血化瘀方治疗慢性阻塞性肺疾病(chronic obstructive pulmonary discase，COPD)急性加重期的临床疗效。方法 采用前瞻性随机对照方法，将60例COPD急性加重期的患者分为2组。治疗组32例，治疗以活血化瘀方为主，并根据中医辨证(痰热阻肺型，痰浊阻肺型，肺肾阴虚型，肺脾气虚型)随证加减。对照组28例，用常规西药治疗。疗程均为2周，观察治疗前后的血液流变学中的全血黏度，肺功能(FEV1、FEV1／FVC％)等指标的变化。结果 治疗组总有效率为90．6％，对照组总有效率为67．9%，两组症状、体征积分治疗后比较差异有显著性(P<0．01)；两组治疗后肺功能比较，差异亦有显著性(P<0．05)：治疗组可改善全血黏度(P<0．05)。结论 两组均可以改善临床症状，但活血化瘀方治疗慢性阻塞性肺疾病急性加重期的疗效较单纯常规西药治疗更佳。

Clinical Observation on Chronic Obstructive Pulmonary Disease of Acute Aggravating Stage Treated with Activating Blood Circulation to Remove Blood Stasis Recipe

ObjectiveTo investigate the clinical efficiency of activating blood circulation to remove blood stasis recipe (ARR) in treatment of patients with chronic obstructive pulmonary disease (COPD) of acute aggravating stage. MethodsAdopting the prospective randomized controlled method, sixty patients with COPD of acute aggravating stage were divided into two groups. Patients in the treated group (n=32) was subdivided into four sub-types, Phlegm-Heat accumulation in Fei type, Phlegm-Dampness accumulation in Fei type, Fei-Shen Yin deficiency type and Fei-Pi Qi deficiency type. They were treated with ARR with modification according to their Syndrome type. Patients in the control group (n=28) were treated with conventional western medicine. The therapeutic course of the two groups was 2 weeks. Changes of indexes including hemorrheological indexes (blood viscosity) and pulmonary function (FEV1, FEV1/FVE%) were observed before and after treatment. ResultsThe total effective rate was 90.6% in the treated group, while it was 67.9% in the control group. The symptom score and pulmonary function in the two groups were significantly different after treatment (P<0.01,P<0.05). In addition, the effect of ameliorating whole blood viscosity in the treated group was better than that in the control group, showing significant difference (P<0.05). ConclusionBoth therapies can improve clinical symptom in patients, but it was showed the effect in those treated with conventional western medicine plus ARR was better than in those treated with conventional western medicine alone.