GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects |
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| Authors: | Anna Grzywacz Iwona Ma?ecka Micha? Korostyński Ryszard Przew?ocki Przemys?aw Bieńkowski Jerzy Samochowiec |
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| Affiliation: | 1.Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland;2.Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland;3.Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland |
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| Abstract: | IntroductionLesch''s typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system.Material and methodsWe have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch''s typology and in 145 matched controls.ResultsBesides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls.ConclusionsLesch''s typology may not be related with the genotype of alcoholics – at least in terms of genes with an established role in the development of dependency. |
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| Keywords: | alcohol dependence GABA genetics Lesch''s typology |
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