诱发生理状态下的脑血流动力学的无创光学评估

许多脑部疾病影响人体自我调节能力,可以通过测量脑部血流(Cerebral Blood Flow,CBF)来评估脑自我调节能力。本研究中利用课题组自行开发的近红外光相关谱血流仪来无创检测CBF,同时使用无创连续血压仪来检测人体的平均动脉压(Mean Arterial Pressure,MAP)。10名健康受试者参加了本研究,我们设计70°头上位倾斜试验来诱发血流动力学的变化,并测量了CBF与MAP的动态关系。使用功率谱分析,我们观察到MAP和CBF数据中约0.1 Hz的人体自发性低频振荡,并且在头上位倾斜试验过程中,MAP和CBF的相关性为78%。本研究提供了脑部自我调节能力的评估方法,对于今后的脑功能评估和疾病诊断具有重要意义。

Noninvasive Optical Evaluation of Cerebral Hemodynamics Under Induced-Physiological Status

Many brain diseases affect cerebral autoregulation capability,which could be evaluated by measuring cerebral blood flow(CBF).In this study,a near-infrared diffuse correlation spectroscopy flowmeter device designed by ourself was utilized to noninvasively detect CBF.Meanwhile,the mean arterial pressure(MAP)was continuously measured by a Finometer device.A total of 10 healthy subjects participated in a study protocol of 70°head-up-tilting,in order to create changes in cerebral hemodynamics.The dynamic relationship between CBF and MAP was investigated.With approach of power spectral analysis,we observed the spontaneous low frequency oscillation at the 0.1 Hz.In addition,the correlation between CBF and MAP was 78%during the headuptilting test.This study provides an approach for the evaluation of cerebral autoregulation capability,thus holding potential for future brain functional assessment and disease diagnosis.