腹腔镜探查对结核性腹膜炎诊断价值的Meta分析

目的采用Meta分析方法评价腹腔镜探查对结核性腹膜炎的诊断价值。方法计算机检索PubMed、The Cochrane Library、Web of Science、WanFang Data、CNKI和VIP数据库,搜集腹腔镜探查诊断结核性腹膜炎的相关研究,检索时限均从1990年1月1日至2019年4月1日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件、Meta-Disc 1.4软件及Stata SE15.0软件进行Meta分析。结果共纳入10个研究,包括1 098例患者。Meta分析结果显示:腹腔镜探查诊断结核性腹膜炎的合并敏感度、特异度、阳性似然比、阴性似然比、诊断比值比和SROC曲线下面积分别为:0.98[95%CI(0.96,0.98)]、0.85[95%CI(0.78,0.91)]、4.78[95%CI(1.98,11.54)]、0.06[95%CI(0.03,0.12)]、111.40[95%CI(36.55,339.58)]和0.971 1,Q*指数为0.921 6。结论现有证据表明,腹腔镜探查对结核性腹膜炎的诊断有较高的敏感度和特异度,腹腔镜探查可作为实验室检查无法明确病因时,对结核性腹膜炎患者的诊断及治疗手段。受纳入研究的数量和质量的限制,上述结论尚需开展更多研究予以证实。

Laparoscopic exploration in the diagnosis of tuberculous peritonitis: a meta-analysis

Objectives To evaluate the clinical value of laparoscopic exploration in the diagnosis of tuberculous peritonitis by meta-analysis. Methods The Cochrane Library, PubMed, Web of Science, WanFang Data, CNKI and VIP databases were electronically searched to collect relevant studies on the diagnostic value of laparoscopic exploration in diagnosing tuberculous peritonitis from January 1 st, 1990 to April 1 st, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. The Rveman 5.3, Meta-DiSc 1.4 and Stata SE15 software were used for statistical analysis and the receiver operating characteristic curve(SROC) was drawn. Results A total of 10 studies involving 1098 patients were included. The results of meta-analysis showed that the pooled sensitivity,specificity, positive likelihood ratio, negative likelihood ratio, diagnosis odds ratio and area under the curve of SROC were0.98(95%CI 0.96 to 0.98), 0.85(95%CI 0.78 to 0.91), 4.78(95%CI 1.98 to 11.54), 0.06(95%CI 0.03 to 0.12), 111.40(95%CI36.55 to 339.58) and 0.971 1, respectively and the Q* was 0.9216. Conclusions The existing evidence shows that laparoscopic exploration has higher sensitivity and specificity in the diagnosis of tuberculous peritonitis. Laparoscopic exploration can be used as a diagnosis and treatment tool for patients with tuberculous peritonitis in case the laboratory test cannot determine the origin. Due to the limited quality and quantity of included studies, the above results should be validated by more studies.