Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour |
| |
| Authors: | J R Dimmock E Erciyas S K Raghavan D L Kirkpatrick |
| |
| Affiliation: | College of Pharmacy, University of Saskatchewan, Saskatoon, Canada. |
| |
| Abstract: | 1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably. |
| |
| Keywords: | |
|
