首页 | 本学科首页   官方微博 | 高级检索  
检索        


Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour
Authors:J R Dimmock  E Erciyas  S K Raghavan  D L Kirkpatrick
Institution:College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
Abstract:1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号