Regulation of G protein-coupled receptor signaling by scaffold proteins |
| |
Authors: | Hall Randy A Lefkowitz Robert J |
| |
Institution: | Department of Pharmacology, Emory University School of Medicine, Atlanta, Ga, USA. |
| |
Abstract: | The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold proteins, which can link the receptors to various signaling intermediates and intracellular effectors. The multicomponent nature of G protein-coupled receptor signaling pathways makes them ideally suited for regulation by scaffold proteins. This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|