Severe Churg-Strauss syndrome with mediastinal lymphadenopathy treated with interferon therapy |
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| Authors: | Lesens Olivier Hansmann Yves Nerson Jacques Pasquali Jean Gasser Bernard Wihlm Jean Christmann D |
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| Affiliation: | Service des Maladies Infectieuses et Tropicales, Clinique Médicale A, Fédération des Services de Médecine Interne, H?pital Civil, 1 place de l'H?pital, B.P. 426, 67091 Cedex, Strasbourg, France |
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| Abstract: | We report a case of severe Churg-Strauss syndrome (CSS) with mediastinal eosinophilic lymphadenopathy, with relapse after standard therapy with steroids and cyclophosphamide, subsequently treated with interferon (IFN) alpha 2b. Our report shows that mediastinal lymph nodes mimicking lymphoma may be one of the clinical manifestations of CSS. We also show that patients with CSS who are resistant to first-line therapy and for whom hypereosinophilia is thought to play an important role may benefit from treatment with IFN. |
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