非溃疡性消化不良患者血浆及胃窦粘膜一氧化氮含量的变化

目的:探讨非溃疡性消化不良(NUD)患者血浆及胃窦粘膜中一氧化氮(NO)含量有无变化以及它在NUD疾病过程中的可能作用和临床意义。方法:应用亚硝酸盐法测定31例NUD患者血浆NO含量,其中12例患者胃液体排空延迟(NUD_2组),19例患者胃液体排空正常(NUD_1组);再用NADPH—黄递酶组织化学方法结合彩色图像分析系统测定这些患者胃窦粘膜NO含量,并以14例相当的正常人作对照。结果:NUD_2组患者血浆NO含量明显高于NUD_1组及对照组(P<0.01);胃窦粘膜中NO含量NUD_2组亦显著高于NUD_1组及对照组(P<0.01)。西沙必利使NUD患者胃液体排空功能及临床症状改善,也使其血浆和胃窦粘膜中NO含量明显升高(P<0.01)。结论NO含量升高与胃液体排空延迟相关,NO在NUD的疾病过程中可能有一定的作用。

Nitric Oxide in Plasma and Antral Mucosa in Non-ulcer Dyspe psia

Purpose: To explore the change of nitric oxide(NO) in plasma and antral mucosa and whether NO may play a role in non-ulcer dyspcpsia(NUD). Methods: levels of NO in plasma were mea-sured by levels of NO3 /NO2 in 31 patients with MUD, including 12 patients with delayed gastric liquid emptying (NUD2 group), 19 patients with normal gastric emptying (NUD1 group); NO in antral mucosa was studied by NADPH-diaphorase histochemical methods, and quantitatively measured with image anal-yser. 14 "healthy subjects" as control group. Results; The plasma NO in NUD2 group was significantly higher than that in NUD1 and control groups (P<0.01); NO of antral mucosa in NUD2 group was much more than that of NUD1 and control groups(P<0.01). Cisapride improved the gastric emptying and symptoms, and elevated significantly NO in plasma and antral mucosa in NUD2 group(P<0.01). Conclu-sion: Abnormal change of NO was associated with delayed gastric liquid emptying, and play some roles in NUD.