西酞普兰联合丁螺环酮治疗老年抑郁症的临床研究

目的：探讨西酞普兰联合丁螺环酮治疗老年抑郁症的临床疗效和不良反应。方法：将80例符合CCMD-3诊断标准的老年抑郁症患者随机分为观察组和对照组各40例，观察组采用西酞普兰联合丁螺环酮治疗，对照组仅用西酞普兰，疗程8周，采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和副反应量表（TESS）评定疗效和不良反应。结果：治疗后4周末、8周末观察组的HAMD和HAMA平均减分率高于对照组，差异均存在统计学意义（P〈0．05）；两组间的不良反应发生率差异无显著性，均未出现严重不良反应。结论：西酞普兰联合丁螺环酮治疗老年抑郁症安全有效，不良反应少而轻，值得临床推广应用。

Clinical study on the efficacy of citalopram combined with buspirone in treatment of senile depression

Objective： To explore the clinical efficacy and side effects of citalopram combined with buspirane in the treatment of senile depression. Methods： 80 cases patients confirmed to CCMD-3 standards were randomly divided into the intervention group（40 cas- es） and control group （40 cases）.The intervention group were treated citalopram combined with buspirone, the control group were treated citalopram; After treatment for4, 8 weeks, the therapeutic effects and side effects were evaluated by HAMD, HAMA and TESS. Results： The score of HAMD and HAMA of intervention group was significantly lower than that of control group, there were significant differences （P 〈 0.05）. The differences of the side effects between the two groups were not significant, no serious adverse reactions. Conclusion： Citalopram combined with buspirone is an effective and safe antidepressant in the treatment ＇of the senile depression, fewer and lighter side-effects, and worthy of being recommended for use in clinical practice.