| 急性白血病细胞p53基因表达 |
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| 引用本文： | 鹿全意 孟莉. 急性白血病细胞p53基因表达[J]. 河南医学研究, 1998, 7(4): 345-346 |
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| 作者姓名： | 鹿全意 孟莉 |
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| 作者单位： | [1]河南省人民医院血液科 [2]深圳蛇口区人民医院内儿科 |
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| 摘 要： | 目的：检测急性白血病细胞内ｐ５３基因表达情况。方法：３Ｈ－ｄＡＴＰ标记基因探针的斑点杂交。结果：急性淋巴细胞白血病（ＡＬＬ）表达ｐ５３ＲＮＡ水平与正常对照类似，急性非淋巴细胞白血病（ＡＮＬＬ）中５９．４％表达低水平ｐ５３或表达缺失，ｐ５３表达缺失在Ｍ４、Ｍ５中多见。结论：急性白血病细胞中存在ｐ５３ＲＮＡ表达异常。
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| 关 键 词： | 急性白血病；p53基因；基因表达 |
The Detection of p53 Gene Expression in Acute Leukemia Cells |
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| Lu Quanyi Meng Li Zhang Yin et al. The Detection of p53 Gene Expression in Acute Leukemia Cells[J]. Henan Medical Research, 1998, 7(4): 345-346 |
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| Authors: | Lu Quanyi Meng Li Zhang Yin et al |
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| Abstract: | Objective: p53 gene expression was detected in acute Leukemia cells.Methods: DNA RNA Dot blot with 3H dATP probe.Results: p53 mRNA in all cells was normal,p53 RNA expression was very lower or deficiency in 59.4% ANLL cells and p53 gene deficience was frequent in M 4、M 5.Conclusion: Aberrant expression of gene was present in acute leukemia cells.The probe with 3 H dATP can be used in detecting gene expression. |
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| Keywords: | actue leukemia p53 gene gene expression |
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