复方丹参滴丸治疗糖尿病性视网膜病变的临床研究

目的:观察复方丹参滴丸对糖尿病性视网膜病变患者视功能恢复的治疗作用。方法:收集糖尿病性视网膜病变Ⅰ~Ⅲ期的患者共42例(78眼)。随机分成两组,治疗组43眼,给予复方丹参滴丸口服,10粒/次,3次/日,连续用药3个月。对照组35眼,给予V itB1和路丁C,观察患者治疗前后视力、眼底、视野、荧光血管造影及视觉电生理的变化。结果:复方丹参滴丸治疗组的视力较治疗前明显提高,与对照组比较差异有显著性(P<0.05)。治疗组视网膜小出血斑、微血管瘤数目及视野灰度值(MD)较治疗前明显减少,与对照组相比差异有显著性(P<0.05)。治疗组视觉诱发电位P100波的潜伏期小于对照组,波幅高于对照组;视网膜电流图a、b波的潜伏期小于对照组,波幅高于对照组,差异有显著性(P<0.05)。结论:复方丹参滴丸对糖尿病性视网膜病变患者视力的改善有显著疗效,对视网膜微血管瘤和小出血斑有良好的控制作用,对视功能的恢复有积极作用。

Clinical Study of Diabetic Retinopathy Treated by Compound Danshen Dripping Pills

OBJECTIVE: To observe the therapeutic effect of compound danshen dripping pills in visual function recovery of diabetic retinopathy. METHODS: 42 patients(78 eyes) with diabetic retinopathy of I-III phase were divided into two groups in random. 43 eyes were treated with compound danshen dripping pills and the other 35 eyes with vitamin BI and Luding C for three months. The visual acuity, fundus, visual field, fundus fluorescein angiography and visual electro-physiology were observed. RESULTS: The visual acuity in treated group were significantly improved after treatment and had significant difference with those in control group (P < 0.05). The number of micro-hemorrage, microaneurysm and the mean defect (MD) of visual field in treated group decreased obviously after treatment and had significant difference with that in control group (P < 0.05). The latent period of P100 wave and a, b wave in treated group were shorter than control group, and the wave amplitude were higher than that in control group. CONCLUSION: The compound danshen dripping pills can improve the visual acuity, control the micro-hemorrage and microaneurysm of fundus and have the effect in visual function recovery of diabetic retinopathy.