2型糖尿病伴非酒精性脂肪肝患者血清 nesfatin-1水平的变化 |
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引用本文: | 卢东晖,张帆,连晓芬.2型糖尿病伴非酒精性脂肪肝患者血清 nesfatin-1水平的变化[J].重庆医学,2015(24). |
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作者姓名: | 卢东晖 张帆 连晓芬 |
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作者单位: | 北京大学深圳医院内分泌科,广东深圳,518036 |
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基金项目: | 深圳市科创委科技研发项目 |
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摘 要: | 目的:观察2型糖尿病(T2DM)伴或不伴非酒精性脂肪肝(NAFLD)患者血清 nesfatin-1水平的变化。方法检测T2DM 组(211例,其中 T2DM 不伴 NAFLD 组98例,T2DM 伴 NAFLD 组113例)和对照组(NGT)组(75例)的空腹血清 nesfa-tin-1水平,同时测定身高、体质量、血糖(GLU)、血脂谱、胰岛素水平(INS)、糖化血红蛋白(HbA1c)、谷丙转氨酶水平(ALT),计算BMI、胰岛素抵抗指数(HOMA-IR)。结果T2DM 组血清 nesfatin-1水平均明显高于 NGT 组(P <0.05),T2DM 组中 T2DM 伴NAFLD 亚组血清 nesfatin-1水平高于 T2DM 不伴 NAFLD 组(P <0.05)。T2DM 组 nesfatin-1与病程中度相关(r=-0.477,P <0.05)T2DM 组中脂肪肝的发生与 BMI、TG、nesfatin-1有关(P <0.05)。结论nesfatin-1可能参与 T2DM 及 NAFLD 的发生。
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关 键 词: | 糖尿病 2 型 人体质量指数 非酒精性脂肪肝 nesfatin-1 |
Changes of serum nesfatin-1 levels in type 2 diabetes patients with nonalcoholic fatty liver |
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Abstract: | Objective To investigate serum nesfatin-1 levels in type 2 diabetes (T2DM)patients with or without nonalcohol-ic fatty liver(NAFLD).Methods The hight,weight,serum GLU,lipid profiles,INS,HbA1c,ALT,nesfatin-1 levels were measured in 21 1 T2DM patients98 without NAFLD(TD2M without NAFLD group)and 1 13 with NAFLD(TD2M with NAFLD group)] and 75 normal subjects(NGT group).BMI、HOMA-IR were also calculated.Results The serum nesfatin-1 level was significantly higher in T2DM group than those in NGT group(P <0.05),and T2DM with NAFLD group had higher nesfatin-1 level than T2DM without NAFLD group (P < 0.05 ).There was a close relation between nefastin-1 of T2DM group and course of disease (r=-0.447,P <0.05).NAFLD existed a significant correlation with BMI、TG and nesfatin-1 (P <0.05).Conclusion nesfatin-1 may partially contribute to the pathogenesis of T2DM and NAFLD. |
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Keywords: | diabetes mellitus type 2 body mass index nonalcoholic fatty live nesfatin-1 |
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