| 异帕米星联合头孢哌酮/舒巴坦与美罗培南治疗呼吸机相关性肺炎患者的对照研究 |
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| 引用本文： | 陆非平,陈炜,张静妹,刘龙,古旭云,王锁柱.异帕米星联合头孢哌酮/舒巴坦与美罗培南治疗呼吸机相关性肺炎患者的对照研究[J].中华医院感染学杂志,2010,20(19). |
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| 作者姓名： | 陆非平 陈炜 张静妹 刘龙 古旭云 王锁柱 |
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| 作者单位： | 北京世纪坛医院ICU,北京,100038 |
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| 摘 要： | 目的 观察异帕米星联合头孢哌酮/舒巴坦与美罗培南治疗呼吸机相关性肺炎患者的临床疗效及安全性.方法 选择80例住院呼吸机相关性肺炎患者,随机分组接受异帕米星联合头孢哌酮与美罗培南治疗,对比其临床疗效,细菌学疗效与不良反应.结果 异帕米星联合头孢哌酮/舒巴坦组有效率为75.0%,细菌清除率为72.2%;美罗培南组有效率为80.0%,细菌清除率为71.1%,均P值>0.05;两组不良反应均较低且轻微.结论 异帕米星联合头孢哌酮/舒巴坦的疗效与美罗培南相似,不良反应轻,可作为呼吸机相关性肺炎的一线经验用药.
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| 关 键 词： | 异帕米星 头孢哌酮/舒巴坦 美罗培南 呼吸机相关性肺炎 |
Empirical Treatment for Patients with Ventilator-associated Pneumonia:A Controlled Clinical Trial of Cefoperazone/Sulbactam Combined with Isepamicin vs Meropenem |
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| LU Fei-ping,CHEN Wei,ZHANG Jing-shu,LIU Long,GU Xu-yun,WANG So-zhu.Empirical Treatment for Patients with Ventilator-associated Pneumonia:A Controlled Clinical Trial of Cefoperazone/Sulbactam Combined with Isepamicin vs Meropenem[J].Chinese Journal of Nosocomiology,2010,20(19). |
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| Authors: | LU Fei-ping CHEN Wei ZHANG Jing-shu LIU Long GU Xu-yun WANG So-zhu |
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| Institution: | LU Fei-ping,CHEN Wei,ZHANG Jing-shu,LIU Long,GU Xu-yun,WANG So-zhu(Shijitan Hospital,Beijing 100038,China) |
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| Abstract: | OBJECTIVE To compare the clinical efficiency and safety either of isepamicin combined with cefoperazone/sulbactam(IPM+CPZ/SUL) or meropenem(MRP) for the empirical treatment of ventilator-associated pneumonia(VAP).METHODS Eighty patients with VAP were randomized divided into two groups and received IPM+CPZ/SUL or MRP.The clinical and bacteriological efficiency as well as the side reaction of the two groups were compared.RESULTS The clinical response rate was 75.0% for IPM+CPZ/SUL and 80.0% for MRP.The bacter... |
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| Keywords: | Isepamicin Cefoperazone/sulbactam Meropenem Ventilator-associated pneumonia |
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