| 许旺细胞联合C5a受体拮抗剂移植脊髓损伤大鼠的电生理及后肢功能变化 |
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| 引用本文： | 王玉成,周江波.许旺细胞联合C5a受体拮抗剂移植脊髓损伤大鼠的电生理及后肢功能变化[J].中国组织工程研究与临床康复,2011,15(36). |
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| 作者姓名： | 王玉成 周江波 |
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| 作者单位： | 1. 天津市静海县医院神经外科,天津市,301600
2. 天津市第四中心医院神经外科,天津市,300140 |
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| 摘 要： | 背景:C5a通过增强脊髓损伤后早期炎症反应参与了脊髓损伤后的继发性损伤,C5a受体拮抗剂能有效阻断这一过程.目的:观察许旺细胞移植联合C5a受体拮抗剂对脊髓损伤大鼠神经功能恢复的影响.方法:Wistar大鼠80只建立脊髓损伤动物模型后随机分成4组.①空白对照组尾静脉注射培养液组+腹腔注射生理盐水.②细胞移植组尾静脉注射许旺细胞.③C5a受体拮抗剂组腹腔注入C5a受体拮抗剂.④联合组尾静脉注射许旺细胞,同时腹腔注入C5a受体拮抗剂.结果与结论:下肢运动功能评价联合移植组优于细胞移植组和C5a受体拮抗剂组,细胞移植组和C5a受体拮抗剂组优于对照组.细胞移植组和联合组有SRY基因表达.HRP阳性神经纤维数:联合组>胞移植组与C5a受体拮抗剂组>空白对照组,且各组之间差异有显著性意义(P < 0.01).联合组大鼠体感诱发电位及运动诱发电位的潜伏期、波幅明显优于其他3组(P < 0.05或P < 0.01).提示许旺细胞移植和C5a受体拮抗剂联合应用可促进脊髓损伤大鼠神经突触的再生,改善其肢体运动功能和电生理功能.
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| 关 键 词： | 许旺细胞 C5a受体拮抗剂 脊髓损伤 细胞移植 电生理 大鼠 |
Effects of complement 5a receptor antagonists combined with Schwann cells transplantation on recovery of electrophysiological and neurological function in rats with spinal cord injury |
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| Wang Yu-cheng,Zhou Jiang-bo.Effects of complement 5a receptor antagonists combined with Schwann cells transplantation on recovery of electrophysiological and neurological function in rats with spinal cord injury[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(36). |
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| Authors: | Wang Yu-cheng Zhou Jiang-bo |
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| Institution: | Wang Yu-cheng1,Zhou Jiang-bo2 1Department of Neurosurgery,Tianjin Jinghai Hospital,Tianjin 301600,China,2Department of Neurosurgery,Tianjin Fourth Central Hospital |
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| Abstract: | BACKGROUND:Complement 5a(C5a) by enhancing the early inflammatory response after spinal cord injury participates in the spinal cord secondary injury.C5a receptor antagonists can effectively block this process.OBJECTIVE:To investigate the effect of Schwann cells transplantation and C5a receptor antagonists on repair of rat spinal cord injury.METHODS:Eighty healthy female Wistar rats were randomly divided into 4 groups:control group,cell transplantation group,C5a receptor antagonist group and combination grou... |
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