| 诱导骨髓间充质干细胞分化移植后的心脏电生理特性 |
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| 引用本文： | 刘博武,吕安林,燕学波,黄炜,候婧,李垚. 诱导骨髓间充质干细胞分化移植后的心脏电生理特性[J]. 中国组织工程研究与临床康复, 2011, 15(32). DOI: 10.3969/j.issn.1673-8225.2011.32.042 |
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| 作者姓名： | 刘博武 吕安林 燕学波 黄炜 候婧 李垚 |
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| 作者单位： | 解放军第四军医大学西京医院心内科,陕西省西安市,710032 |
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| 摘 要： | 背景:随着生物技术的发展,使用骨髓间充质干细胞修复心肌梗死后或者心肌肥厚心肌组织的电生理学成为当今研究热点.目的:概述骨髓间充质干细胞向心肌细胞诱导分化移植后的电生理特征的研究进展.方法:应用计算机检索PubMed数据库,Springer Link数据库,Science Direct数据库,CNKI数据库2000-01/2010-10文献,检索词分别为"bone marrow mesenchymal stem cells,cardiac/heart,electrophysiology/ electrophysiological characteristics"和"骨髓间充质干细胞,心脏,电生理".选择骨髓间充质干细胞向心肌细胞诱导分化移植后的电生理特征的文章,无论观察对象是人或者动物均纳入检索标准.排除重复研究或Meta分析类文章.结果与结论:收集到208篇相关文献,排除162篇不符合标准的文献,共纳入46篇符合标准的文献.经分析得出以下结论:骨髓间充质干细胞诱导分化移植后,在动物试验模型中和心肌梗死或心肌肥厚的患者中均可有效的改善心功能,为心肌病的临床治疗提供了崭新的策略.而移植后所生成的心肌样细胞在改善心脏功能的同时,对心脏电生理也产生了一定的影响.
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| 关 键 词： | 骨髓间充质干细胞 诱导 分化 移植 电生理特性 |
Cardiac electrophysiological characteristics after transplantation of differentiated bone marrow mesenchymal stem cells |
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| Liu Bo-wu,Lü An-lin,Yan Xue-bo,Huang Wei,Hou Jing,Li Yao. Cardiac electrophysiological characteristics after transplantation of differentiated bone marrow mesenchymal stem cells[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(32). DOI: 10.3969/j.issn.1673-8225.2011.32.042 |
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| Authors: | Liu Bo-wu Lü An-lin Yan Xue-bo Huang Wei Hou Jing Li Yao |
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| Affiliation: | Liu Bo-wu,Lü An-lin,Yan Xue-bo,Huang Wei,Hou Jing,Li Yao Department of Cardiology,Xijing Hospital Affiliated to Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China |
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| Abstract: | BACKGROUND: With the development of biotechnology, the electrophysiology of repairing heart tissues of myocardial infarction or myocardial hypertrophy by using bone marrow mesenchymal stem cell has become a hot spot. OBJECTIVE: To overview the research progress of cardiac electrophysiological characteristics after transplantation of induced differentiation of bone marrow mesenchymal stem cells into cardiomyocytes. METHODS: The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for pa... |
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