隐匿性哮喘患者血浆炎症标记物与肺小气道功能的关系 |
| |
引用本文: | 田方,张文武,王立军,程明刚,廖全全,李莉. 隐匿性哮喘患者血浆炎症标记物与肺小气道功能的关系[J]. 岭南急诊医学杂志, 2008, 13(1): 14-16 |
| |
作者姓名: | 田方 张文武 王立军 程明刚 廖全全 李莉 |
| |
作者单位: | 广东省南方医科大学附属深圳宝安医院,518101 |
| |
基金项目: | 广东省深圳市医学重点学科建设项目,广东省深圳市科技计划 |
| |
摘 要: | 目的:探讨隐匿性哮喘(concealed asthma,CA)患者血浆炎症标记物与肺小气道功能的关系。方法:选择连续确诊的(经支气管激发试验)隐匿性哮喘急性发作期患者(n=30)行肺小气道功能测定,以ELISA方法测定其血中C-反应蛋白(CRP)、白细胞介素-6(IL-6)和IL-4水平。另选健康查体者(n=21)作为对照。结果:与对照组比较,CA急性发作期患者存在肺小气道功能减退(P〈0.05);血中CRP、IL-6及IL-4水平显著升高(P〈0.05),并与FEF25%-75%、FEF75%-85%呈负相关。结论:隐匿性哮喘患者存在肺小气道功能减退,血中炎症标记物水平显著升高,并与其小气道功能的减退呈负相关。
|
关 键 词: | 隐匿性哮喘 C-反应蛋白 白细胞介素-6 肿瘤坏死因子-α 肺功能 小气道 |
Correlation between Serum Levels of Inflammatory Biomarkers and Small Airway Ventilatory Function in Patients with Concealed Asthma |
| |
Affiliation: | TIAN Fang, ZHANG Wen-wu, WANG Li-jun, et al(Affiliated Bao' an Hospital of Nanfang Medical University, Shenzhen, Guangdong Province ,518101) |
| |
Abstract: | Objective:To investigate the correlation between the serum levels of inflammatory biomarkers and small airway ventilatory function in patients with concealed asthma (CA). Methods:Consecutive patients (n=30) with CA confirmed by specific or non specific provocation test were included in this study and people with health-examination (n= 21) were choose as control. There lung function was determined and the C-reactive protein (CRP),interleukin-6 (IL-6) and IL-4 was measured by enzyme-linked immunosorbent assays. Result:Compared to the control, the small airway ventilatory function of CA patients was impaired. The serum levels of CRP, IL-6 and TNF-α was significantly increased (P〈0.05) and there was a negative correlation between the levels of inflammatory biomarkers and FEF25%-75%,FEF75%-85%, P〈0.01). Conclusion:Patients with concealed asthma have a impaired small airway ventilatory function and a higher serum level of CRP, IL-6 and IL-4. |
| |
Keywords: | concealed asthma c-reactive Protein interleukin-6 interleukin-4 lung function small airway |
本文献已被 CNKI 维普 万方数据 等数据库收录! |
|