隐匿性哮喘患者血浆炎症标记物与肺小气道功能的关系

目的：探讨隐匿性哮喘（concealed asthma，CA）患者血浆炎症标记物与肺小气道功能的关系。方法：选择连续确诊的（经支气管激发试验）隐匿性哮喘急性发作期患者（n=30）行肺小气道功能测定，以ELISA方法测定其血中C-反应蛋白（CRP）、白细胞介素-6（IL-6）和IL-4水平。另选健康查体者（n=21）作为对照。结果：与对照组比较，CA急性发作期患者存在肺小气道功能减退（P〈0.05）；血中CRP、IL-6及IL-4水平显著升高（P〈0.05），并与FEF25%-75%、FEF75%-85%呈负相关。结论：隐匿性哮喘患者存在肺小气道功能减退，血中炎症标记物水平显著升高，并与其小气道功能的减退呈负相关。

Correlation between Serum Levels of Inflammatory Biomarkers and Small Airway Ventilatory Function in Patients with Concealed Asthma

Objective：To investigate the correlation between the serum levels of inflammatory biomarkers and small airway ventilatory function in patients with concealed asthma （CA）. Methods：Consecutive patients （n=30） with CA confirmed by specific or non specific provocation test were included in this study and people with health-examination （n= 21） were choose as control. There lung function was determined and the C-reactive protein （CRP）,interleukin-6 （IL-6） and IL-4 was measured by enzyme-linked immunosorbent assays. Result：Compared to the control, the small airway ventilatory function of CA patients was impaired. The serum levels of CRP, IL-6 and TNF-α was significantly increased （P〈0.05） and there was a negative correlation between the levels of inflammatory biomarkers and FEF25%-75%,FEF75%-85%, P〈0.01）. Conclusion：Patients with concealed asthma have a impaired small airway ventilatory function and a higher serum level of CRP, IL-6 and IL-4.