环氧化酶-2抑制剂联合肌肉松弛剂治疗膝关节骨性关节炎的临床研究

目的：研究环氧化酶-2(COX-2)抑制剂联合肌肉松弛剂治疗膝骨性关节炎的临床疗效与副作用。方法：随机分组，单盲给药，观察联合用药组和对照组各43例，联合用药组给予COX-2抑制剂罗非昔布及肌肉松弛剂盐酸乙哌立松，对照组单独给予罗非昔布，比较两组用药后临床症状改善情况并进行统计分析。结果：经8周治疗后联合用药组显效率为34．2％，对照组显效率为18．5％，两组间有显著统计学差异。平均Womac关节炎指数评分和平均OA严重程度指数改变联合用药组均显著优于对照组。结论：肌肉松弛剂能有效缓解关节周围肌肉因疼痛而产生的保护性痉挛，延缓因关节活动限制引起的关节退行性变和纤维性强直。与环氧化酶-2抑制剂联合应用对膝关节骨性关节炎有很好的疗效。

Specific inhibitors of cyclooxygenase 2 in combine with muscle relaxant in the treatment of knee osteoarthritis

Objective:To observe the efficacy and safety of Specific inhibitor of cyclooxygenase 2(COX 2)in combine with muscle relaxant in the treatment of knee osteoarthritis(OA) Methods: Randomized trial, two controlled groups each with 43 cases with knee OA were included statistically analyzed the difference of therapeutic efficacy between experiment group treated with Specific inhibitor of COX 2 (Rofecoxib) in combine with muscle relaxant and control group treated with Rofecoxib only Results: After 8 weeks of treatment, the combined medication group got a apparent efficiency ratio of 34 2% while the control group only had 18 5% Experiment group provided efficacy advantages over control group in therapeutic efficacy,WOMAC and OA Severity index Conclution: muscle relaxant can efficiently relax the protective muscle spasm around the jiont due to the pain and defer the degeneration and fibrous ankylosis of the jiont compare with limited activity Cyclooxygenase 2(COX 2) in combine with muscle relaxant in the treatment of knee osteoarthritis (OA) is more effectively than use COX 2 only