Clinical analysis of 275 cases of acute drug-induced liver disease |
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Authors: | Li Lei Jiang Wei and Wang Jiyao |
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Institution: | (1) Department of Digestive Disease, Zhongshan Hospital, Fudan University, Shanghai, 200032, China |
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Abstract: | In order to analyze the causative drugs, clinical manifestation and pathological characteristics of the patients with acute
drug-induced liver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseases according
to Maria Criterion and hospitalized in Zhongshan Hospital of Fudan University were retrospectively reviewed. Each was determined
by drug history, clinical symptoms and signs, laboratory tests and therapeutic effects. In 41 cases, the diagnosis was confirmed
by liver biopsy. The proportion of acute drug-induced liver disease among all of the acute liver injuries was annually increased.
The most common drugs which induced acute liver injuries were traditional Chinese herb medicine (23.3%, 64/275 cases), antineoplastic
(15.3%, 42/275), hormones and other immunosuppressant agents (13.8%, 38/275), antihypertensive drugs and other cardiovascular
drugs (10.2%, 28/275), NSAIDs (8.7%, 24/275) respectively. Hepatocellular injury was the predominant type in these cases (132
cases, 48%). The principal clinical manifestation included nausea (54.8%), fatigue (50.2%), jaundice (35.6%). 27.9% patients
were asymptomatic. Most patients were cured with good prognosis. The total effective rate was 94.2% after treatment. The clinicians
should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease. |
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Keywords: | hepatitis acute drug-induced herbs hepatotoxicity |
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