| 原发性视网膜色素变性抗凋亡治疗研究进展 |
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| 引用本文： | 李素芳,魏锐利. 原发性视网膜色素变性抗凋亡治疗研究进展[J]. 眼科新进展, 2003, 23(4): 293-295 |
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| 作者姓名： | 李素芳 魏锐利 |
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| 作者单位： | 200003,上海市,第二军医大学长征医院眼科 |
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| 基金项目： | 国家自然科学基金(编号:30070800)~~ |
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| 摘 要： | 视网膜色素变性的病理学基础是色素上皮细胞和锥杆细胞的渐进性死亡。这些细胞的死亡是经过凋亡的形式完成的。bcl—2和睫状神经营养因子能抑制这种自然进程的的凋亡。本文从抗细胞凋亡的角度综述了视网膜色素变性的基因治疗。
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| 关 键 词： | 视网膜色素变性 基因治疗 凋亡 |
| 文章编号： | 1003-5141(2003)04-0293-03 |
| 修稿时间： | 2003-05-22 |
Progress in the research of anti-apoptosis therapy of retinitis pigmentosa |
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| LI Su-Fang,WEI Rui-Li From the. Progress in the research of anti-apoptosis therapy of retinitis pigmentosa[J]. Recent Advances in Ophthalmology, 2003, 23(4): 293-295 |
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| Authors: | LI Su-Fang WEI Rui-Li From the |
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| Affiliation: | LI Su-Fang,WEI Rui-Li From the Department of Ophthalmology,the Changzheng Hospital of the Second Military Medical University,Shanghai 200003,China |
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| Abstract: | Basic pathologic changes of retinal pigmentosa are programmed by death of retinal pigment eipthelium cell and photoreceptor cell. The death of these cells is via apoptosis. bcl-2 and ciliary nearotrophic factor can suppress cell apoptosis, which is an natural process. This artical summarized the research progression of anti-apoptosis therapy of retinal pigmentosa. |
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| Keywords: | retinitis pigmentosa gene therapy apoptosis |
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