克山病病区粮对大鼠全血谷胱甘肽过氧化物酶活力及体内抗氧化能力的影响

1.比较了病区和非病区玉米、大米饲料及动物房常备饲料喂养的大鼠全血GSH-Px活力。结果表明:常备组高于非病区组,后者又高于病区组。同时测定的体外用维生素C氧化血红蛋白生成的高铁血红蛋白、胆绿蛋白和Heinz小体的百分率。各组雌鼠之间无显著差异,而雄鼠的结果与GSH-Px活力呈反相关。 2.喂以病区玉米饲料三个月造成乏硒的大鼠补充硒(Na_2SeO_3)50天后,血硒和红细胞GSH—Px活力均升到接近常备饲料组大鼠的水平。

STUDIES ON BLOOD GLUTATHIONE PEROXIDASE ACTI- VITY AND ANTIOXIDATIVE POTENTIAL IN RATS FED GRAINS FROM KESHAN DISEASE ENDEMIC AREAS

1. Experiments were conducted to compare the blood glutathione peroxi-dase activity of rats fed low selenium diets (0.0042 and 0.0084ppm Se) mainly composed of rice, corn and soybean grown in Keshan Disease endemic areas with that of rats fed the contrast diets (0.073 and 0.074 ppm Se) composed of the same grains grown in non-endemic areas and with that of rats fed stock diets (0.307 ppm Se). The enzyme activities of the endemic grain-feeding groups were lower than that of the non-endemic grain-feeding groups, but the enzyme activities of these groups were significantly lower than that of the stock diet group. The difference of the percentage of ascorbic acid-induced oxidation of hemoglobin to methemoglobin, choleglobin and Heinz bodies in vitro in different groups were in the same trend as that of the glutathione peroxidase activity.2. When rats were fed the low selenium diets for three months supplementing with sodium selenite, both the blood selenium levels and glutathione peroxidase activities were increased to the levels of the stock diet group within 50 days.