Attention and psychomotor speed decline in patients with temporal lobe epilepsy: a longitudinal study |
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Authors: | Piazzini Ada Turner Katherine Chifari Rosanna Morabito Alberto Canger Raffaele Canevini Maria Paola |
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Affiliation: | Epilepsy Center, St. Paolo Hospital, University of Milan, Via A. Di Rudini 8, 20142 Milan, Italy. ada.piazzini@ao-sanpaolo.it |
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Abstract: | PURPOSE: To assess the possible cognitive alterations in epilepsy patients compared with controls over 5 years, and to investigate the clinical variables mainly implied in mental impairment. METHODS: In our longitudinal single-center study, 50 patients with temporal lobe epilepsy (TLE) and 50 controls were administered the same battery of comprehensive neuropsychological tests at baseline and after 5 years. RESULTS: TLE patients showed a significant impairment in attention and psychomotor speed compared with controls after 5 years, while the other cognitive domains did not exhibit any important changes. This worsening was mainly related to the duration of epilepsy, the age at onset, a history of tonic-clonic seizures and a low educational level. CONCLUSIONS: We believe that tapping the attention and psychomotor speed decline in TLE patients should be considered relevant for future research, in order to achieve a deeper understanding of the cognitive dimensions of this field. |
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