First prenatal diagnosis of X-linked lymphoproliferative disease. |
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| Authors: | J Skare S Madan J Glaser D Purtilo H Nitowsky V Pulijaal A Milunsky |
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| Affiliation: | Center for Human Genetics, Boston University School of Medicine, Massachusetts 02118. |
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| Abstract: | A family study was performed in order to diagnose X-linked lymphoproliferative (XLP) disease in a fetus. The molecular genetic analysis indicated that the fetus, as well as its healthy 7-year-old brother, inherited XLP. Analysis of immunoglobulin subclasses from the 7-year-old brother supported the DNA-based diagnosis. This is the first XLP family of African descent. |
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