丙型肝炎病毒重叠其它肝炎病毒感染的血清学及预后调查

检测８９２例各类肝病患者血清中甲型（ＨＡＶ）、乙型（ＨＢＶ）、丙型（ＨＣＶ）、戊型（ＨＥＶ）肝炎病毒标志物。丙型肝炎患者占肝病患者１３．６％（１２１／８９２），其中５９．５％（７３／１２１）为重叠感染。ＨＣＶ与ＨＢＶ重叠感染最常见，占６４．６％（４７／７３），其次是ＨＣＶ、ＨＡＶ和ＨＢＶ（１３．７％），ＨＣＶ与ＨＥＶ（１８．２％），ＨＣＶ与ＨＡＶ（６．８％），及ＨＣＶ、ＨＢＶ和ＨＥＶ（６．８％）。ＨＣＶ重叠感染者重症肝炎生率及病死率均显著高于单纯ＨＣＶ感染者。结果提示，重叠感染是ＨＣＶ感染者病情恶化及死亡的重要因素。

Serological and Prognostic Investigation on Superinfection of HCV and Other Hepatitis Virus

HAV、HBV、HCV and HEV markers were detected in the sera of the 892 patients with liver diseases. The positive rate of HCV marker was 13.6%(121/892). 59.5% of the patients with HCV infection suffered from superinfection. The most common mode of superinfection was HCV and HBV (84.9%). The next modes were as follows; HCV and HAV and HBV (13.7%), HCV and HEV (8.2%), HCV and HAV (6.8%), HCV and HBV and HEV (6.8%) respectively. The morbidity of severe hepatitis and mortality in the patients with HCV superinfection were significantly higher than those in the patients with HCV infection alone. The results suggest superinfection may play an important role in the aggravation and death of patients infected with HCV.