| Affiliation: | 1. Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands;2. Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, the Netherlands;3. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands;4. Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands;5. Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands |
| Abstract: | Inflammatory mechanisms, like microglial activation, could be involved in the pathogenesis of Alzheimer's disease (AD). (R)-[11C]PK11195 (1-(2-chlorophenyl)-N-methyl-N-1(1-methylpropyl)-3-isoquinolinecarboxamide), a positron emission tomography (PET) ligand, can be used to quantify microglial activation in vivo. The purpose of this study was to assess whether increased (R)-[11C]PK11195 binding is present in AD and mild cognitive impairment (MCI), currently also known as “prodromal AD.” |
