Analyzing HLA-G polymorphisms in children from women with scleroderma |
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| Authors: | Christophe Picard Julie Di Cristofaro Doua F. Azzouz Sami B. Kanaan Jean Roudier Nathalie C. Lambert |
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| Affiliation: | 1. INSERM UMR 7268, Marseille, France;2. INSERM UMRs1097, Laboratoire d’Immunogénétique de la Polyarthrite Rhumatoïde, Marseille, France;3. Service de Rhumatologie, Hôpital Ste Marguerite, AP-HM, Marseille, France |
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| Abstract: | Embryos during pregnancy and organs during transplantation, express high levels of soluble HLA-G (sHLA-G) molecules for successful implantation and protection against maternal immune cells or recipient’s cells. We and others have shown that women with scleroderma (SSc) carry cells/DNA arising from pregnancy, so-called fetal microchimerism (Mc) more often and in higher quantities than healthy women decades after delivery. |
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