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Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice

Authors:	Mufida B. El-Ghundi Theresa Fan Joanna M. Karasinska John Yeung Millee Zhou Brian F. O’Dowd Susan R. George

Affiliation:	(1) Department of Pharmacology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, ON, Canada, M5S 1A8;(2) Department of Medicine, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, ON, Canada, M5S 1A8;(3) Centre for Addiction and Mental Health, Toronto, ON, Canada, M5T 1R8;(4) Present address: Center for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada;(5) Department of Pharmacology and Medicine, University of Toronto, Medical Sciences Building, Room 4358, 1 Kings College Circle, Toronto, ON, Canada, M5S 1A8;

Abstract:	Rationale and objectives Amphetamine-induced sensitization is thought to involve dopamine D₁ receptors. Using mice lacking dopamine D₁ receptors (D₁^−/−), we found that they exhibited blunted sensitization to low doses of amphetamine, while others using different treatment and testing regimens reported inconsistent results. We investigated whether experimental variables, alteration in gene expression or cholinergic input played a role in amphetamine-induced responses.

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