Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide |
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| Authors: | Ray Chui and Katerina Dorovini-Zis |
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| Affiliation: | (1) Division of Neuropathology, Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada |
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| Abstract: | Background Chemokines are emerging as important mediators of CNS inflammation capable of activating leukocyte integrins and directing the migration of leukocyte subsets to sites of antigenic challenge. In this study we investigated the expression, release and binding of CCL2 (MCP-1) and CCL3 (MIP-1α) in an in vitro model of the human blood-brain barrier. |
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