Copy number variation of the SELENBP1 gene in schizophrenia |
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| Authors: | Shirly Amar Ofer Ovadia Wolfgang Maier Richard Ebstein RH Belmaker Dan Mishmar Galila Agam |
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| Affiliation: | (1) Psychiatry Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Mental Health Center, Beersheva, Israel;(2) Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer Sheva, Israel;(3) Department of Psychiatry, University of Bonn, Bonn, Germany;(4) Department of Psychology, Hebrew University, Mt. Scopus and S. Herzog Memorial Hospital, Jerusalem, Israel |
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| Abstract: | Background Schizophrenia is associated with rare copy-number (CN) mutations. Screening for such alleles genome-wide, though comprehensive, cannot study in-depth the causality of particular loci, therefore cannot provide the functional interpretation for the disease etiology. We hypothesized that CN mutations in the SELENBP1 locus could associate with the disorder and that these mutations could alter the gene product's activity in patients. |
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