EB病毒感染与鼻咽癌发病机制的关系

鼻咽癌（nasopharyngeal carcinoma，NPC）是一种在中国南方、台湾、新加坡及特定地域的其它国家或地区很常见的肿瘤，其发病因素尚不明确。目前，还未发现与NPC发生过程的遗传因素有关的主要基因；而一些环境因素可能与诱发NPC有关。如食用腌鱼和长期暴露于硫酸蒸汽，研究指出EB病毒（Epstein—Barr virus，EBV）与NPC发病机理密切相关。为了探索NPC与EBV之间的关系，我们建立了10个NPC细胞株。经过广泛研究，我们认为EBV通过IgA受体（分泌组分蛋白）介导的细胞内吞作用，可能仅感染鼻咽肿瘤细胞，而不感染化生上皮细胞。我们发现EBV对于促进NPC进展起着重要作用，但并不参与启动及促进NPC的发生。

Relationship between Epstein-Barr virus infection and nasopharyngeal carcinoma pathogenesis

Nasopharyngeal carcinoma among Chinese living in South China, countries or regions in distinct areas. （NPC） is one of the common cancers Taiwan, Singapore, and several other The etiological factors have not been clearly identified yet. So far, no major gene related with hereditary factor has been identified in NPC carcinogenesis; however, some environmental factors, such as consumption of salted fish and long-term exposure to sulfuric-acid vapor, have been tentatively linked to NPC induction, while research has proposed that there is a close association between Epstein-Barr virus （EBV） and NPC pathogenesis. To investigate the relationship between NPC and EBV, we have established ten NPC cell lines. After extensive investigation, we conclude that EBV may establish an infection only in nasopharyngeal neoplastic cells, not in metaplastic epithelial cells, through the IgA receptor （secretory component protein ）-mediated endocytosis. Our observations indicate that EBV plays an important role in enhancement of NPC progression, but is involved in neither the initiation nor the promotion of NPC pathogenesis.