冠心病者颈动脉内膜中层厚度与血清脂联素水平相关性

目的探讨老年冠心病患者颈总动脉平均内膜中层厚度(IMT)与血清脂联素(APN)水平的相关性。方法将69例老年冠心病患者根据颈总动脉平均IMT分成3组:内膜增厚组、斑块形成组和管腔狭窄组。采用酶联免疫法测定血清的APN水平,并与25例年龄和性别相当的健康体检者(对照组)进行比较。结果冠心病组APN水平显著低于对照组,而且降低程度与IMT狭窄程度一致,管腔狭窄组APN降低尤为明显。结论APN参与了老年冠心病患者颈动脉狭窄的发生和发展过程,与颈动脉狭窄病理生理改变关系密切。APN为评价颈动脉IMT病变程度提供了一条新的线索。

Relationship between the IMT of common carotid artery and the serum level of adiponection in elderly patients with coronary heart disease

Objective To investigate the relationship between the intima media thickness (IMT) of common carotid artery and the serum level of adiponection (APN) in elderly patients with coronary heart disease (CHD). Methods Sixty-nine elderly patients with CHD were divided into three groups according to the degree of the IMT: the intima thickness group, the plaque formation group and the vascular stenosis group. Serum APN was measured using ELISA, compared with those in 25 healthy subjects. Results The serum level of APN in CHD patients was significantly lower than that in control group. In addition, there was association between APN levels and IMT degree. Conclusions APN is significantly correlated with IMT, suggesting that APN is involved in the development of the vascular stenosis in the patients with CHD. APN may be a new marker for surveillance on IMT.