No positive effects of OP-1 device on the incorporation of impacted graft materials after 8 weeks: a bone chamber study in goats |
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Authors: | Hannink Gerjon Schreurs B Willem Buma Pieter |
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Institution: |
a Orthopaedic Research Lab, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
b Department of Orthopaedics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands |
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Abstract: | Background?Bone morphogenetic proteins (BMPs) have the potential to improve clinical outcome after hip revision surgery by improving graft incorporation and implant fixation. However, impaction of cancellous bone grafts and TCP/HA bone substitute mixed with OP-1 device in a bone chamber in goats in a previous study led to reduced fibrous tissue ingrowth after 4 weeks. New bone formation was not promoted by OP-1. In the current study we examined whether this reduction represented a final loss of ingrowth or was just a delay, and whether the reduction can be overcome and ultimately results in a better late ingrowth.
Methods?Bone chambers with impacted allografts and impacted TCP/HA granules mixed with 2 doses of OP-1 device were implanted in proximal medial goat tibias. Impacted allografts and TCP/HA not treated with OP-1 served as controls. After 8 weeks, the incorporation was evaluated using histology and histomorphometry.
Results?Histology revealed evidence of bone graft incorporation, which proceeded in a similar way in both allografts and TCP/HA, with and without the addition of OP-1. After 8 weeks, no difference in bone ingrowth was found between the OP-1 groups and their controls. It was only in the allografts that the addition of OP-1 resulted in more fibrous tissue ingrowth.
Interpretation?We conclude that the previously observed delay in fibrous tissue ingrowth can be only partially overcome. |
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