Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c |
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Authors: | Degg Natalie L Weil Michael M Edwards Alan Haines Jackie Coster Margaret Moody John Ellender Michele Cox Roger Silver Andrew |
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Institution: | Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, United Kingdom. |
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Abstract: | Ionizing radiation (IR) is a well-characterized carcinogen in humans and mice. The BALB/c mouse strain is unusually sensitive to IR-induced tissue damage and cancer development in a range of organs, suggestive of a partial defect in DNA damage response. This has been confirmed by finding BALB/c-specific functional polymorphism in Prkdc, a gene on mouse chromosome 16 that encodes the catalytic subunit of DNA-dependent protein kinase. Prkdc(BALB) has been associated with increased susceptibility to IR-induced mammary and lymphatic neoplasia. Here, we provide evidence that chromosome 16 segments from BALB/c interact with Apc(Min) (multiple intestinal neoplasia) and specifically enhance IR-induced adenoma development in the upper part of the small intestine. |
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