| 抗癌药物多相脂质体139的气相色谱分析 |
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| 引用本文： | 孙毓庆,赵立平,顾学裘. 抗癌药物多相脂质体139的气相色谱分析[J]. 沈阳药科大学学报, 1984, 0(3) |
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| 作者姓名： | 孙毓庆 赵立平 顾学裘 |
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| 作者单位： | 沈阳药学院分析化学教研室，沈阳药学院分析化学教研室，沈阳药学院药剂研究室 |
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| 摘 要： | 市售油酸是多相脂质体139的主要成分。经 GC—MS 证明,市售油酸是脂肪酸的混合物,油酸(18:1,9C)含量最高,约为70%,用气相色谱法测定多相脂质体139的油酸或市售油酸的含量,样品需预处理。预处理分三步:1.加热使水与油分层。2.用0.5NNaOH—甲醇将分出的油层皂化。3.将脂肪酸的皂化物用甲醇及 BF_3—乙醚酯化。而后进行气相色谱分析,定量精密度一般 CV<3%。
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| 关 键 词： | 多相脂质体的气相色谱分析 抗癌药物气相色谱分析 气相色谱 |
GAS CHROMATOGRAPHIC ANALYSIS OF THE INJECTOINS OE POLYPHASE LIPOSOME 139(ANTITUMOR AGENTS) |
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| Sun Yuqing Zhao Liping Gu Xueqiu. GAS CHROMATOGRAPHIC ANALYSIS OF THE INJECTOINS OE POLYPHASE LIPOSOME 139(ANTITUMOR AGENTS)[J]. Journal of Shenyang Pharmaceutical University, 1984, 0(3) |
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| Authors: | Sun Yuqing Zhao Liping Gu Xueqiu |
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| Affiliation: | Koo Hsuchchiu |
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| Abstract: | The commercial oleic acid which is the mixture of the fatty acids(oleic acid contents appr.70%)is the main composition of injections of the polyphase liposome 139.The content of commercial oleie acid or oleic acid of 139 was determinated by G.C.analysis.The preparation method of the sample of 139 consist of three steps.The first is to separate oil from water.The second,the oil is saponified with 0.SN NaOH-methanol.The third,the saponated fatty acids are esterified with methanol and BF_3—ether.The coefficient of variation of this G.C.analytical method is less than 3%. |
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| Keywords: | GC analysis of polyphase liposome 139 GC analysis of antitumor agents GC |
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