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Changes in the renin angiotensin system during the development of colorectal cancer liver metastases |
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| Authors: | Jaclyn H Neo Eleanor I Ager Peter W Angus Jin Zhu Chandana B Herath Christopher Christophi |
| Institution: | (1) Department of Surgery, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia;(2) Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia |
| Abstract: | BackgroundBlockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model. In this work we defined the expression of the various components of the RAS in both tumor and liver during the progression of this disease. |
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