| 甲状腺机能亢进症红细胞微量元素锌、铜、铁缺陷研究 |
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| 引用本文： | 沈建国,童钟杭,夏惕勤,俞锡林.甲状腺机能亢进症红细胞微量元素锌、铜、铁缺陷研究[J].浙江大学学报(医学版),1996(6). |
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| 作者姓名： | 沈建国 童钟杭 夏惕勤 俞锡林 |
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| 作者单位： | 浙江医科大学附属第一医院内分泌科，浙江医科大学附属儿童医院 |
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| 摘 要： | 采用原子吸收分光光谱技术建立了一种适合临床应用的重复性及准确性良好的红细胞微量元素测定法。作者检测４０例正常人及５０例甲亢病人的血浆及红细胞锌、铜、铁含量，结果发现甲亢者存在红细胞锌、铜缺陷。红细胞锌与甲状腺激素呈负相关关系；红细胞铜与甲状腺激素呈正相关关系；红细胞锌显著降低（Ｐ＜０．００１），与Ｔ４、Ｔ３呈负相关（Ｐ＜０．０１）；红细胞铜显著增加（Ｐ＜０．０１），与Ｔ４呈正相关（Ｐ＜０．０５）。初诊甲亢患者治疗后红细胞锌明显增加（Ｐ＜０．０５），红细胞铜明显降低（Ｐ＜０．０５），提示甲状腺激素干扰红细胞锌、铜代谢。
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| 关 键 词： | 甲状腺机能亢进／病理生理学 红细胞／化学 锌／血液 铜／血液 铁／血液 甲状腺素／生理学 |
DEFECTS OF TRACE ELEMENTS ZINC,COPPER AND IRON IN ERYTHROCYTES OF PATIENTS WITH HYPERTHYROIDISM |
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| Shen Jianguo, Tong Zhonghang, Xia Tiqin,et al.DEFECTS OF TRACE ELEMENTS ZINC,COPPER AND IRON IN ERYTHROCYTES OF PATIENTS WITH HYPERTHYROIDISM[J].Journal of Zhejiang University(Medical Sciences),1996(6). |
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| Authors: | Shen Jianguo Tong Zhonghang Xia Tiqin |
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| Abstract: | The contents of erythrocyte zinc, copper and iron in 40 normal subjects and 50 patients with hyperthyroidism were determined by means of atom absorption spectrophotometry. The results suggested that erythrocyte zinc values in hyperthyroidism were significantly lower than normal value(P<0.01),with a considerably negative correlationship between the concentration of erythrocyte zinc and plasma thyroxine and triiodothyronine(P<0.01); erythrocyte copper values were much higher than the normal value in hyperthyroidism(P<0.01)with remarkably positive correlationship between erythrocyte copper and thyroxine(P< 0.05). After treatment erythrocyte zinc values increased obviously(P<0.05). It indicated that thyroid hormone might affect erythrocyte zinc and copper metabdism. |
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| Keywords: | Hyperthyroidism/physiopathol Erythrocytes/chem Zinc/blood Copper/blood Iron/blood Thyroxine/physiol |
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