A randomized double blind,placebo controlled trial of topical Tripterygium wilfordii in rheumatoid arthritis: reanalysis using logistic regression analysis |
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| Authors: | Cibere Jolanda Deng Zhaozhi Lin Yuanchang Ou Runmei He Yiting Wang Zhiqiang Thorne Anona Lehman Allen J Tsang Ian K Esdaile John M |
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| Affiliation: | Arthritis Research Centre of Canada and the Canadian HIV Trials Network, Vancouver, British Columbia, Canada. |
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| Abstract: | OBJECTIVE: To assess the efficacy of topical Tripterygium wilfordii (TW), a Chinese herbal therapy, in rheumatoid arthritis (RA). METHODS: A 6 week randomized double blind placebo controlled study of 61 patients with RA meeting American College of Rheumatology (ACR) criteria was conducted in China. The primary outcome was a modified ACR-20 response rate, analyzed by logistic regression analysis. RESULTS: The modified ACR-20 response rate differed significantly (topical TW 58% vs placebo 20%; p = 0.002). There was an 8.1-fold (95% CI 1.9-35.4) increase in the modified ACR-20 response for the TW compared to the placebo group, adjusted for age and erythrocyte sedimentation rate. CONCLUSION: Topical TW appears efficacious for the treatment of RA, but larger studies are needed. |
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