实验性急性胰腺炎早期胰组织氧供及微循环

于家兔急性出血性胰腺炎早期阶段研究了胰组织氧供及胰腺微循环的变化。实验证明急性胰腺炎后１０ｍｉｎ即可见到胰组织氧分压下降（５．５７±１．０２ｋＰａ）及胰腺微循环血流减少（１１．８６％±４．９１％），至２ｈ末仍明显降低（６．０２±１．７ｋＰａ／９．１４％±５．８７％），与发病前（９．１１±１．３４ｋＰａ／２１．７１％±１１．４０％）有明显差别。诱发急性胰腺炎后１及２ｈ均见血清α－淀粉酶（１２２７．５７±７８８．２７及１６９８．２９±６８１．０３Ｕ／Ｌ）较急性胰腺炎前（５２６．８６±１５６．３４Ｕ／Ｌ）明显增高。病理检查证明疾病模型符合急性出血性胰腺炎变化。由此认为研究胰组织氧供较单纯研究血液循环（包括微循环）更重要，设法改善胰组织氧供是进行实验与临床治疗的必要措施。

Experimental Research on Pancreatic Oxygen Supply and Microcirculation in Early Stage of Acute Pancreatitis

Changes of oxygen supply of pancreatic tissue and blood microcirculation of pancreas were investigated in early stage of acute hemorrhagic pancreatitis of rabbits. Experiments proved decrease of partial pressure of oxygen in pancreatic tissue(5. 57±1. 02kpa) and microcirculation in pancreas(11. 86%±4. 91%) could be seen 10 minutes immediately after production of acute pancreatitis(AP).The decreasing was still significant(6. 02±1.47kpa/9.14%±5.87%)at 2nd hour after AP. Compared with the levels before disease (9.11±1.34 kpa/ 21. 71%±11. 40%) difference was obvious. Serum α-amylase at 1and 2 hours after AP (1 227.57±788. 27U/L and 1 698. 29±681.03U/L) higher than the values before pancreatitis (526.86±156 . 34U/L) significantly.Pathologic examination showed the features of acute hemorrhagic pancreatitis. It suggested that measuring of oxygen supply of pancreatic tissue was more important than blood circulation (including microcirculation) . To get a methed to improve oxygen supply of pancreatic tissue was a necessary therapeutic measure in experimental and clinical treat