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| 植入用缓释氟尿嘧啶犬皮下局部毒性实验 | |
| 引用本文： | 陈向红,许健健,喻平,周丽春,窦红漫,孙昕. 植入用缓释氟尿嘧啶犬皮下局部毒性实验[J]. 安徽医药, 2006, 10(6): 412-413 |
| 作者姓名： | 陈向红 许健健 喻平 周丽春 窦红漫 孙昕 |
| 作者单位： | 1. 安徽医科大学病理学教研室 2. 合肥工业大学控释药物研究室 3. 安徽中医学院病理教研室,安徽,合肥,230022 |
| 基金项目： | 科技部"攀登计划" |
| 摘 要： | 目的观察植入用缓释氟尿嘧啶(商品名:中人氟安)单点一次性犬皮下植药后局部毒性反应,了解皮下给药的安全性。方法用专用植入针,分大、中、小三个不同剂量于犬后腿皮下植入缓释氟尿嘧啶,对照组植入不含氟尿嘧啶的空白辅料颗粒。结果大、中剂量组植药部位有局部发红,毛发稀疏、皮下硬结等局部刺激反应,小剂量组无病理变化。结论植入缓释氟尿嘧啶单点一次性植入剂量500 mg,产生的组织损伤是可修复的。 |
| 关 键 词： | 植入用缓释氟尿嘧啶 局部毒性 犬 |
| 收稿时间： | 2006-02-21 |
| 修稿时间： | 2006-02-21 |
Experimental study of local toxicity on dog-subcutaneous tissue injection of slow-released 5-FU |
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| CHEN Xiang-hong,XU Jian-jian,YU Pin,et al. Experimental study of local toxicity on dog-subcutaneous tissue injection of slow-released 5-FU[J]. Anhui Medical and Pharmaceutical Journal, 2006, 10(6): 412-413 | |
| Authors: | CHEN Xiang-hong XU Jian-jian YU Pin et al |
| Affiliation: | Department of Pathology,Anhui Medical University, Hefei 230032, China |
| Abstract: | Aim To study local toxicity on dog-subcutaneous tissue injection of slow-released 5-FU.Methods Slow-released 5-FU were injected by special instrument.Results High and middle dosages result in local inflammation reaction,but low dosage does not.Conclusion Slow-released 5-FU injected without a second time for 500mg is secure dosage. |
| Keywords: | injection of slow-released 5-FU local toxicity dog |
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