一氧化碳和一氧化氮在新生儿缺氧缺血性脑病中的变化与神经行为测定的关系

目的　 探讨一氧化碳 (CO)和一氧化氮 (NO)在新生儿缺氧缺血性脑病 (HIE)中的作用 ,与新生儿神经行为测定(NBNA)之间的关系及早期评估预后的价值 ,以便及时给予正确治疗。 方法 　对 5 1例新生儿HIE患儿血浆CO和NO水平进行检测 ,并与 2 0例正常新生儿对照组比较 ,同时结合 2 0项新生儿神经行为测定。 结果 　与正常新生儿对照组比较 ,5 1例新生儿HIE患儿血浆CO、NO水平显著增高 ,但轻、中度新生儿HIE两组之间NO水平无显著性差异 ,而重度者血浆CO、NO水平显著增高 ,并且病情程度与NBNA评分呈负相关。 结论 　CO和NO在新生儿HIE的发病过程中具有重要意义 ,而且CO和NO的变化与NBNA之间也具有一定关系。

The alterations of plasma CO and NO in the neonatal HIE and their relations to NBNA

Objective To investigate the alterations of CO and NO in neonatal HIE and their relations to NBNA,and the value of early estimating prognosis in order to give correct treatments promptly.Methods Plasma CO and NO levels were studied in 51 newborn infants with HIE,and 20 healthy neonates served as control, and in the same time, NBNA which contained 20 items was combined.Results The plasma CO and NO levels in 51 newborn infants with HIE were significantly higher than those in the normal controls; The plasma NO levels have no significant differences between light and moderate newborn infants with HIE; The plasma CO and NO levels in the newborn infants with severe HIE; And the degree of illness was negatively related to the grades of NBNA.Conclusion CO and NO are significant to the pathogenesis of neonatal HIE, and there were some relationship between the alterations of CO and NO and NBNA.