我国4城市成年人群甲型肝炎病毒血清抗体流行率调查

目的 了解我国大城市成年人群甲型肝炎抗体流行率.方法 调查北京、上海、武汉、广州4个城市20～88岁当地常住居民2390人,采用微粒了酶免疫分析法榆测血清甲型肝炎病毒抗体(抗-HAV IgG).利用Excel建立数据库,采用SPSS13.0统计软件进行数据分析.结果北京30～39岁年龄组女性抗-HAV IgG阳性率为64.58%(62/96),男性45.57%(36/79),女性抗HAVIgG阳性率高于男性,χ~2=6.358,P=0.012,差异有统计学意义.北京和,"州成人抗-HAV IgG流行率随年龄增加而上升,北京20岁～、30岁～、40-49岁组分别为54.22%(90/166)、56.00%(98/175)和67.18%(88/131),χ~2=4.76,P=0.03,差异有统计学意义;广州20岁～、30岁～、40岁～,50岁～、60～88岁组分别为52.83%(56/106)、52.50%(63/120)、82.46%(94/114)、89.80%(88/98)和96.77%(60/62),χ~2=72.58,P<0.01,差异有统计学意义.而上海和武汉则末见此趋势.北京、上海、广州和武汉20～39岁人群抗-HAV IgG阳性率分别为55.13%(188/341)、63.93%(429/671)、52.65%(119/226)和78.37%(308/393).结论 4个城市20～39岁年龄组人群扰-HAV IgG流行率较低.建议对城市20～39岁年龄组易感人群进行甲型肝炎疫苗接种.

A study on seroprevalence of anti-HAV IgG in adults of cities in China

Objective To investigate the seroprevalence of anti-HAV IgG in adults of 4 cities in China.Methods Serum samples were collected from 2390 local residents aged between 20-88 years from Beijing,Shanghai,Wuhan and Guangzhou.The anti-HAV IgG in sera was detected with a micropanicle enzyme immunoassay (MEIA).Results The anti-HAV lgG seroprevalence in female of 30-39 years in Beijing(64.58%,62/96)was higher than that in male(45.57%36/79))(χ~2=6.358,P=0.012).It increased with age in adults of Beijing and Guangzhou.The rates were 54.22%(90/166),56.00%(98/175)and 67.18%(88/131)for the 20-,30-and 40-49 age groups in Beijing(χ~2=4.76,P=0.03);and 52.83%(56/106),52.50%(63/120),82.46%(94/114),89.80%(88/98)and 96.77%(60/62)for the 20-,30-,40-,50-and 60-88 age groups in Guangzhou,respectively(χ~2=72.58,P<0.01).This trend was not found in Shanghai and Wuhan(χ~2=0.96,2.99;P=0.33,0.08 respectively).The seroprevalence rates of anti-HAV IgG in the 20-39 age group of Beijing,Shanghai,Guangzhou and Wuhan were 55.13%(188/341),63.93%(429/671),52.65%(119/226)and 78.37%(308/393),respectively.Conclusion The mroprevalence rates ofanti-HLW IgG in young adults aged 20-39 years of the four cities are relatively low,and HAV vaccination should be suggested for the susceptible population of this age group in China.