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The distribution of GABA and glycine response in the mouse brain using Xenopus oocytes |
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| Authors: | A Asanuma T Horikoshi K Yanagisawa K Anzai S Goto |
| Affiliation: | 1. Department of Physiology, School of Dental Medicine, Tsurumi University, Yokohama Japan;2. Department of Biochemistry, College of Science and Technology, Nihon University, Tokyo Japan;3. Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Funabashi Japan;1. Materials Science and Technology Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA;2. Theoretical Divisions, Los Alamos National Laboratory, Los Alamos, NM 87545, USA;1. The Forth Affiliated Hospital of Hebei Medical University, No. 12 Health Road, Shijiazhuang 050011, PR China;2. Hebei Medical University, No. 361 Zhongshan East Road, Shijiazhuang 050017, PR China |
| Abstract: | Injection of mRNA from different regions of the central nervous system (CNS) of the mouse into the Xenopus oocyte caused a difference in the relative glycine to gamma-aminobutyric acid (GABA) response of the oocyte. Glycine caused the response in oocytes injected with brainstem mRNA but hardly in oocytes injected with cerebrum mRNA and in oocytes injected with cerebellum mRNA. In contrast, GABA caused the response in oocytes injected with mRNA from each of the 3 parts of the CNS. These obvious regional differences may reflect the distribution of the receptors to each plausible neurotransmitter in the CNS. |
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