NF-κB和CXCR4在大肠腺癌中的表达及临床意义

  目的  探讨NF-κB和CXCR4在大肠腺癌发生、发展、浸润转移中的作用及临床意义。  方法  应用免疫组织化学S-P法检测60例大肠腺癌、23例大肠管状腺瘤、25例正常大肠黏膜组织中NF-κB和CXCR4的蛋白表达情况。  结果  大肠腺癌组中的阳性表达均高于大肠管状腺瘤组和正常大肠黏膜组, 大肠管状腺瘤组中NF-κB和CXCR4的阳性表达均高于正常大肠黏膜组, 且大肠腺癌组、大肠管状腺瘤组、正常大肠黏膜组中的阳性表达差异均有统计学意义(P均 < 0.05);大肠腺癌组中NF-κB和CXCR4的阳性表达均与癌组织的浸润深度、有无淋巴结转移有关(P均 < 0.05), 与患者的性别、年龄及癌组织的分化程度无关(P均 < 0.05);大肠腺癌组织中NF-κB和CXCR4的表达呈正相关(r=0.346, P=0.007)。  结论  NF-κB和CXCR4的高表达与大肠腺癌的发生、发展、浸润转移密切相关。 

Expressions of Chemotatic Factor NF-kB and CXCR4 in Colorectal Adeno-carcinoma and Their Clinical Significance

  Objectives  The aim of the current paper was to evaluate the role of the NF-kB and CXCR4 expressions in the oncogenesis, development, infiltration, and metastasis of colorectal adeno-carcinoma (CAdCa) and their clinical significances.  Methods  The expression of NF-KB and CXCR4 in 60 cases with CAdCa, 23 with canalicular adenoma of large intestine (CALl), and 25 with normal colorectal mucosa (NCM) were detected using the SP irnmuno-histochemical method.  Results  The positive expression of NF-KB and CXCR4 were both higher in the CAdCa group compared with the CALl and NCM groups (P < 0.05). This positive expression was higher in the CALl group than in the CNM group. Statistically significant differences have been observed among the expressions in the CAdCa, CALl, and NCM groups (P < 0.05). However, stronger expression of NF-kB and CXCR4 protein was observed in CAdCa, compared with that in normal paraneoplastic tissues (P < 0.05). The positive expression of NF-KB and CXCR4 was closely correlated with the depth of tumor infiltration and the nodal metastasis (P < 0.05). Moreover, a positive correlation was also observed between the expression of NF-KB and CXCR4 in CAdCa (r= 0.346, P= 0.007).  Conclusion  The over-expression of NF-KB and CXCR4 are closely correlated with the infiltration and metastasis of CAdCa.